Tuesday, December 3, 2013

Dapoxetine and Priligy for PE

Dapoxetine is a selective serotonin reuptake inhibitor (SSRI) that was designed specifically for premature ejaculation. SSRIs have been shown to be effective for the treatment of PE. The downside to most SSRIs is that they must be taken daily in order to achieve the desired effect. Dapoxetine was designed to be taken on an "as needed" basis and has been shown to be effective when taken < 3 hours before sexual activity. Studies have shown that dapoxetine increases the intra-vaginal ejaculation latency time (IELT) - the time from vaginal penetration to male orgasm.

The following summary data are taken from the article Dapoxetine: a new option in the medical management of premature ejaculation McMahon, Chris G, Ther Adv Urol. 2012 October; 4(5): 233-251, where the author presents information and results of clinical trials of dapoxetine. We encourage physicians and patients to read the entire document.

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The most comprehensive results from this work comes from the Phase III studies that included 6,081 subjects ranging in age from 18-82. In a double-blind study, each of roughly one-third of patients received one of the following doses: 30mg dapoxetine, 60 mg dapoxetine, or a placebo.


Priligy is the brand name for the Johnson & Johnson's dapoxetine. In 2012, Furiex Pharmaceuticals entered into an agreement with ALZA Corp and Janssen Pharmaceutica (both part of Johnson & Johnson) whereby Furiex will obtain worldwide distribution rights of Priligy. Also in 2012, Furiex entered into a license agreement with Menarini to commercialize Priligy in Europe, most of Asia, Africa, Latin America and the Middle East. Menarini is an international pharmaceutical company.

What should I watch for while using this medicine? If you notice any changes in your vision while taking this drug, call your doctor or health care professional as soon as possible. Call your health care provider right away if you have any change in vision. Contact you doctor or health care professional right away if the erection lasts longer than 4 hours or if it becomes painful. This may be a sign of a serious problem and must be treated right away to prevent permanent damage. If you experience symptoms of nausea, dizziness, chest pain or arm pain upon initiation of sexual activity after taking this medicine, you should refrain from further activity and call your doctor or health care professional as soon as possible. Using this medicine does not protect you or your partner against HIV infection (the virus that causes AIDS) or other sexually transmitted diseases.